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Nutrition

&

Wellness Corner

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References
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Gothenburg, Sweden: Ab Arcanum, 1988, 238–9.

Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs, and Cosmetics, 2d ed. New York

John Wiley & Sons, 1996, 208–10. Whitehouse LW, Znamirouska M, Paul CJ. Devil's Claw  
(Harpagophytum procumbens): no evidence for anti-inflammatory activity in the treatment of arthritic disease. Can Med Assoc J 1983;129:249–51.

Grahame R, Robinson BV. Devil's Claw  (Harpagophytum procumbens): pharmacological and clinical studies. Ann Rheum Dis 1981;40:632.

Chantre P, Cappelaere A, Leblan D, et al. Efficacy and tolerance of Harpagophytum procumbens versus diacerhein in treatment of osteoarthritis. Phytomed 2000;7:177–83. 

Chrubasik S, Zimpfer C, Schutt U, Ziegler R. Effectiveness of Harpagophytum procumbens in treatment of acute low back pain. Phytomed 1996;3:1–10.

Blumenthal M, Busse WR, Goldberg A, et al. (eds). The Complete Commission E Monographs: Therapeutic Guide to Herbal Medicines. Boston, MA: Integrative Medicine Communications, 1998, 120

Blumenthal M, Busse WR, Goldberg A, et al. (eds). The Complete Commission E Monographs: Therapeutic Guide to Herbal 
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Betancor-Fernandez A et al, Screening pharmaceutical preparations containing extracts of turmeric rhizome, artichoke leaf, devil's claw root and garlic or salmon oil for antioxidant capacity. J Pharm Pharmacol. 2003 Jul;55(7):981-6.

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Devil's Claw (Harpagophytum procumbens): no evidence for anti-inflammatory activity in the treatment of arthritic disease. Can Med Assoc J. 1983 Aug 1;129(3):249-51.15. An analytical study, anti-inflammatory and analgesic effects of Harpagophytum procumbens and Harpagophytum zeyheri. 
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 Fiebich BL et al, Inhibition of TNF-alpha synthesis in LPS-stimulated primary human monocytes byHarpagophytum (Devil's Claw)  extract SteiHap 69. Phytomedicine. 2001 Jan;8(1):28-30. 

Andersen ML, Evaluation of acute and chronic treatments with Harpagophytum procumbens on Freund's adjuvant-induced arthritis in rats. J Ethnopharmacol. 2004 Apr;91(2-3):325-30. 

Darshan S, Doreswamy R. Patented antiinflammatory plant drug development from traditional medicine. Phytother Res. 2004 May;18(5):343-57.

Jang MH et al, Harpagophytum procumbens suppresses lipopolysaccharide-stimulated expressions of cyclooxygenase-2 and inducible nitric oxide synthase in fibroblast cell line L929. J Pharmacol Sci. 2003 Nov;93(3):367-71.

Kaszkin M et al, Downregulation of iNOS expression in rat mesangial cells by special extracts of Harpagophytum procumbens derives from harpagoside-dependent and independent 
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An analytical study, anti-inflammatory and analgesic effects of Harpagophytum 
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Lanhers MC Anti-inflammatory and analgesic effects of an aqueous extract of Harpagophytum procumbens. Planta Med. 1992 Apr;58(2):117 

Chrubasik S.Devil's claw extract as an example of the effectiveness of herbal analgesics Orthopade. 2004 Jul;33(7):804-8.

Kundu JK et al, Inhibitory effects of the extracts of Sutherlandia frutescens (L.) R. Br. and Harpagophytum procumbens (Devil's Claw). on phorbol ester-induced COX-2 expression in mouse skin: AP-1 and CREB as potential upstream targets. Cancer Lett. 2005 Jan 31;218(1):21-31

Chantre P, Efficacy and tolerance of Harpagophytum procumbens versus diacerhein in treatment of osteoarthritis. Phytomedicine. 2000 Jun;7(3):177-83

Leblan D et al, Harpagophytum procumbens (Devil's Claw) in the treatment of knee and hip osteoarthritis. Four-month results of a prospective, multicenter, double-blind trial 
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Wegener T Treatment of patients with arthrosis of hip or knee with an aqueous 
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Schulze-Tanzil G et al, Effect of a Harpagophytum procumbens (DevilÂ’s Claw) extract on matrix 
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Therapy of degenerative diseases of the musculoskeletal system with South African devil's claw (Harpagophytum procumbens DC) Wien Med Wochenschr. 1999;149(8-10):254-7.  

Gobel H et al Effects of Harpagophytum procumbens LI 174 (devil's claw) on sensory, motor und 
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(1):13.  

Clarkson C et al, In vitro antiplasmodial activity of abietane and totarane diterpenes isolated from Harpagophytum procumbens 

(devil's claw). Planta Med. 2003 Aug;69 :720-4.

Mahomed IM, Analgesic, antiinflammatory and antidiabetic properties of Harpagophytum 
procumbens DC (Pedaliaceae) secondary root aqueous extract. Phytother Res. 2004 Dec;18(12):982-9. Schmidt AH Fast HPLC for quality control of Harpagophytum procumbens (Devil's Claw ) by using a monolithic silica column: method transfer from conventional particle-based 
silica column. J Chromatogr A. 2005 May 6;1073(1-2):377-81.

Abbey M, Noakes M, Belling GB, Nestel PJ. Partial replacement of saturated fatty acids with almonds or walnuts lowers total plasma cholesterol and low-density-lipoprotein cholesterol. Am J Clin Nutr 1994 May;59(5):995-9. 1994. PMID:16240.

Aggarwal B. Paper presented at the U.S. Defense Department's 'Era of Hope' Breast Cancer Research Program meeting in Philadelphia, PA, October 5, 2005,. reported in NUTRAingredients.com/Europe "Turmeric slows breast cancer spread in mice.". 0.

Ahsan H, Parveen N, Khan NU, Hadi SM. Pro-oxidant, anti-oxidant and cleavage activities on DNA of curcumin and its derivatives demethoxycurcumin and bisdemethoxycurcumin. Chem Biol Interact 1999 Jul 1;121(2):161-75. 1999. PMID:7690.

Arbiser JL, Klauber N, Rohan R, et al. Curcumin is an in vivo inhibitor of angiogenesis. Mol Med 1998 Jun;4(6):376-83. 1998. PMID:7540.

Asai A, Nakagawa K, Miyazawa T. Antioxidative effects of turmeric, rosemary and capsicum extracts on membrane phospholipid peroxidation and liver lipid metabolism in mice. Biosci Biotechnol Biochem 1999 Dec;63(12):2118-22. 1999. PMID:7550.

Balasubramanian K. Molecular Orbital Basis for Yellow Curry Spice Curcumin's Prevention of Alzheimer's Disease. J. Agric. Food Chem., 54 (10), 3512 -3520, 2006. 10.1021/jf0603533 S0021-8561(06)00353-0, Web Release Date: April 20, 2006. 2006.

Calabrese V, Butterfield DA, Stella AM. Nutritional antioxidants and the heme oxygenase pathway of stress tolerance: novel targets for neuroprotection in Alzheimer's disease. Ital J Biochem. 2003 Dec;52(4):177-81.. 2003.

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Deshpande UR, Gadre SG, Raste AS, et al. Protective effect of turmeric (Curcuma longa L.) extract on carbon tetrachloride-induced liver damage in rats. Indian J Exp Biol 1998 Jun;36 :573-7. 1998. PMID:7740.

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